|(αS)-7-((3-羟基-2-苯基丙酰基)氧基)-9-甲基-3-氧杂-9-氮杂三环[3.3.1.02,4]壬烷-9-氧化物氢溴酸水合物|CsnPharm

CAS No.: N/A

Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine.

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400-920-2911

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生物活性

描述Scopolamine N-Oxide HydrobroMide Monohydrate is an anticholinergic agent (a muscarinic acetylcholine receptor antagonist) which induces hyposalivation. In healthy young adults, prolonged intermittent use of scopolamine was found to be a risk factor for the development of dental caries^[1]. Similar to humans, scopolamine acted as an anxiolytic in individual behavioural tests (novel approach test and novel tank diving test). The anxiolytic effect of scopolamine was dose dependent and biphasic, reaching maximum effect at 800 µM. Scopolamine (800 µM) also had an anxiolytic effect in a group behavioural test, as it significantly decreased their tendency to shoal^[2]. Dry mouth was more likely with scopolamine than with methscopolamine or cinnarizine. The use of scopolamine versus placebo in preventing motion sickness has been shown to be effective^[3].
参考文献

实验方案

技术信息

CAS号

N/A

储存条件

分子式

C17H24BrNO6

运输

蓝冰

分子量

418.28

别名

溶解度

DMSO	82.0 mg/mL (196.0 mM)
Ethanol	Insoluble

动物实验配方

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